Votrient 400 Mg

Medically Reviewed by

Dr. Akanksha Kaushal

Dr. Akanksha, Pharm-D

Dr. Akansha is a licensed Clinical Pharmacologist with extensive expertise in pharmacovigilance, prescription analysis, drug information, and safety. She's a dedicated educator and avid learner. Dr. Akansha also reviews medical content on GoodRxMedicine, ensuring accurate pharmaceutical information is accessible to all.

Written by

Julian Carter

Julian Carter

Julian, an MBA in Pharmaceutical Management, brings a dynamic blend of expertise and impact with his contributions at GoodRxMedicine. His dedication and innovative spirit continue to shape a brighter future in pharmaceutical management.

What is Votrient 400

Votrient 400 is an FDA-approved prescription medicine for treating Kidney Cancer and Soft Tissue Sarcoma (STC). It contains Pazopanib, an active ingredient that falls in the Tyrosine Kinase Inhibitor (TKI) class of medicine.

The medicine works by binding and inhibiting the enzyme responsible for the growth of cancerous cells. It also works as an angiogenesis inhibitor and restricts the development of new blood vessels in the tumor. Thus, it works against the Cancer.

Novartis India Ltd, a renowned pharmaceutical company, manufactures Votrient, which you can take after consulting a doctor.

Uses of Votrient 400

Votrient is an anti-cancer medication and is indicated for the following medical conditions:

• Advanced Renal Cell Carcinoma therapy: It is used in adults for the treatment of advanced Kidney Cancer, particularly when the disease has metastasized to other organs.
• Soft Tissue Sarcoma: Votrient is also effective in treating certain types of STC, especially in people who have previously undergone chemotherapy.

Working and benefits of Pazopanib

Pazopanib works by inhibiting several receptor Tyrosine Kinases, including Vascular Endothelial Growth Factor Receptors (VEGFR) and Platelet-Derived Growth Factor Receptors (PDGFR). 

By blocking these receptors, Pazopanib reduces the formation of new blood vessels (angiogenesis) that tumors require for growth and survival. This action not only helps to shrink existing tumors but also prevents the development of new ones, making it a crucial component in managing advanced Cancers.

Taking the prescribed Pazopanib 400 is essential and gives you the following benefits:

• Reduction in tumor size: By inhibiting blood vessels growth that supply nutrients to tumors, the Votrient starves Cancer cells. This leads to decreased tumor mass and potentially improved symptoms.
• Targeted therapy: As a Tyrosine Kinase inhibitor, Pazopanib specifically targets Cancer cells while sparing normal cells. Thus, it leads to a more favorable side effect profile than traditional chemotherapy.
• Management of Cancer symptoms: Pazopanib alleviates various symptoms associated with advanced Cancer. People may experience relief from symptoms such as unexplained weight loss, fatigue, and pain due to the reduction in tumor size and activity.
• Convenient administration: Votrient is consumed orally as a tablet, allowing for ease of use at home compared to intravenous therapies that require hospital visits.

Dosage and how to take Votrient 400

Votrient is an oral tablet and should be consumed by mouth. The medicine contains 400 mg of Pazopanib and should be taken only after consulting a licensed physician. You should consult your doctor to prescribe the ideal dose and time to take the medicine.

For the best results, take Votrient by following the given guidelines:

• Take this medicine at the same time every day.
• Swallow the 400 mg tablet as a whole with a glass of water. Avoid breaking, chewing, or crushing the tablet.
• You need to take this medicine on an empty stomach.
• Take this medicine for the duration as your doctor prescribes.

Side effects

Votrient 400 may cause certain side effects that do not require immediate medical attention. These side effects are well-tolerated and subside as the body adjusts to the prescribed doses.

However, if your side effects persist for longer or worsen, you should consult your doctor and seek treatment.

Some common Votrient side effects are as follows:

• Nausea and vomiting
• Headache
• Fatigue
• Diarrhea
• Taste change
• Hair discoloration
• Low appetite

Interactions

Like all medicines, Votrient may also interact with your medical history or medicines. You must inform your doctor if you have a pre-existing disease or take any medication or supplements.

Drug interactions

Inform your doctor if you take any of the following medicines:

• Atazanavir
• Bepridil
• Fluconazole
• Ketoconazole
• Nelfinavir
• Pimozide
• Tipranavir

Disease interactions

Inform your doctor if you have any of the following medical conditions:

• Heart diseases: People with a history of heart problems or high blood pressure should inform their doctor before taking this medicine.
• Liver disease: This medicine should be used cautiously in people with liver problems. Your doctor may adjust the dose of Votrient.
• Kidney problems: Although this medicine is safe for people with kidney problems, you should always ask your doctor before taking it.
• Hypothyroidism: People with underactive thyroid must consult their doctor before taking this medicine.
• Blood clotting problems: Always inform your doctor if you have a medical history of blood clotting problems.

Food interactions

Do not consume this medicine with grapefruit and its juices. Furthermore, do not consume alcohol along with this medicine.

Precautions

Taking Votrient with caution is advised for the safe use of medicines, such as:

• Do not take this medicine if you are allergic to Pazopanib.
• The medicine is not intended for people below 18 years of age.
• Before taking this medicine, inform your doctor if you take any medicine or supplements. Consult your doctor if you have a history of heart, kidney, or liver problems.
• The medicine is highly unsafe for pregnant and breastfeeding women. It may also cause birth defects if the father is taking this medicine and his partner becomes pregnant.
• Men and women should use effective birth control during and for at least 2 weeks after the last dose of the medicine.
• The medicine may increase the risks of infertility. Therefore, inform your doctor if you are planning to have a baby.
• Do not overdose on this medicine. If you missed a dose, take it as soon as you remember. However, if you are already close to the next dose, continue with the scheduled medicine.

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FAQs

Is Votrient a chemotherapy drug?

No, this medicine is not a conventional chemotherapy medicine. Instead, it works by restricting the development of new blood vessels in the tumor, thus fighting the Cancer. It contains Pazopanib, an active ingredient that falls in the Tyrosine Kinase Inhibitor (TKI) class of medicine. You can consult your doctor and take the prescribed dose.

Does Votrient shrink tumors?

Yes, Votrient can shrink tumors, particularly in advanced Kidney Cancer and Soft Tissue Sarcoma cases. It slows Cancer cell growth and spread. Furthermore, it also restricts the development of new blood vessels in the tumors. Thus, it starves the Cancer cells and leads to their death. Always consult your doctor before taking this medicine.

How will I know if Votrient 400 mg is helping me?

You should take the prescribed dose of medicine at the prescribed time. After consulting your doctor, get a regular examination to help determine that Votrient is working for you. The reduction in tumor size is a positive indication. It can also improve progression-free survival and your symptoms.

Are there any dietary restrictions while taking Votrient 400 mg?

Yes, there are some dietary restrictions while taking Votrient 400. You need to take this medicine on an empty stomach. Avoid taking grapefruit and its juices and alcohol intake during your medication course. Furthermore, drink plenty of water if you are experiencing diarrhea or vomiting-like side effects.

How long does it take for Votrient 400 mg to show effects?

The effectiveness of medicine may vary from person to person. However, the medicine typically begins to show its effects within a few weeks of starting treatment. The exact timeline can vary depending on individual patient factors and the specific type of Cancer being treated.