Uratuf (100+224) Mg Capsules

Medically Reviewed by

Dr. Akanksha Kaushal

Dr. Akanksha, Pharm-D

Dr. Akansha is a licensed Clinical Pharmacologist with extensive expertise in pharmacovigilance, prescription analysis, drug information, and safety. She's a dedicated educator and avid learner. Dr. Akansha also reviews medical content on GoodRxMedicine, ensuring accurate pharmaceutical information is accessible to all.

Written by

Julian Carter

Julian Carter

Julian, an MBA in Pharmaceutical Management, brings a dynamic blend of expertise and impact with his contributions at GoodRxMedicine. His dedication and innovative spirit continue to shape a brighter future in pharmaceutical management.

What is Uratuf 100/224?

Uratuf 100/224 mg capsules are a combination medicine that treats metastatic Colorectal Cancer. Each capsule includes 100 mg of Tegafur and 224 mg of Uracil. Tegafur is a pyrimidine analogue and Uracil is pyrimidone. 

These compounds slows Cancer cell growth and multiplication, thereby destroying the tumor. This medicine is generally provided as part of a chemotherapy treatment to assist patients in controlling symptoms and improving their results. 

The renowned pharma company Dr Reddy's Laboratories Ltd. manufactures this medication.

Uses of Uratuf 100/224

Uratuf 100/224 mg Capsules uses include:

• These capsules are typically used for the first-line metastatic colon and rectum Cancer treatment.
• This medicine promotes a more relaxing recovery following chemotherapy, perhaps lowering the risk of further malignant growths.
• It is frequently used with other anti-cancer medications to improve therapeutic effectiveness.
• Reduces symptoms associated with advanced Colorectal Cancer, increasing overall quality of life.
• Frequently recommended in conjunction with Calcium Folinate to increase efficacy and prevent adverse effects.

Working and benefits of Tegafur and Uracil

Tegafur and Uracil are combined as an anti-cancer medicine for treating specific forms of Cancer, notably Colorectal Cancer. Tegafur functions as a prodrug, transforming it into the active chemotherapeutic agent 5-fluorouracil (5-FU) in the body. This active form inhibits Cancer cells' capacity to make DNA, thus inhibiting their growth and reproduction. 

On the other hand, Uracil plays an essential function by reducing the breakdown of 5-FU, allowing it to remain active in Cancer cells for longer. This, in turn, reduces risk of new tumors.

Together, Tegafur and Uracil provide the following benefits:

• Effective for Colorectal Cancer: Tegafur and Uracil are generally used to treat metastatic Colorectal Cancer, offering an effective oral chemotherapy alternative.
• Lower toxicity: Tegafur and Uracil offer a superior safety profile than typical intravenous chemotherapy regimens, resulting in fewer side effects and more patient compliance.
• Convenient administration: As an oral medicine, it is more convenient than intravenous therapies, allowing patients to control their therapy at home.
• Combination with other therapies: It works well when paired with other medications, such as Calcium Folate or immunotherapy, to improve therapeutic results.
• Reduction in recurrence: Tegafur and Uracil can considerably lower the chance of Cancer recurrence in individuals following surgery.

Dosage and how to take Uratuf 100/224

Take Uratuf 100/224 capsules as your doctor directs for maximum effectiveness. Here are some general usage instructions:

• It is advisable to take the medicine at the same time daily for the desired outcomes.
• Swallow the capsule whole with a glass of water without chewing or opening it.
• Stay well-hydrated during the treatment.
• The dosage will be determined by your specific condition and treatment plan, which your doctor will decide.

Side effects

While Uratuf capsules are generally well-tolerated when used as directed, some individuals may experience side effects, which are typically mild and diminish as your body adapts to the medication. Commonly reported side effects include:

• Nausea
• Vomiting
• Fatigue
• Mouth sores
• Diarrhea

If any of these side effects make you worried or persist, it’s essential to contact your healthcare provider for guidance and support.

Interactions

Uratuf 100/224 capsules can interact with some prescription or over-the-counter medicines, underlying health issues, and certain food items, increasing the chance of side effects.

Drug interactions

Uratuf may interact with several medications, affecting their efficacy or elevating the likelihood of adverse effects. Potential drug interactions include:

• Aquasol A
• Capecitabine
• Fluorouracil
• Phenytoin
• Isotretinoin

This is not the entire list of probable interactions. Consult your doctor about other possible interactions between Uratuf and any medicines you are taking.

Disease interactions

Uratuf 100/224 mg capsules can also interact with several disease conditions, affecting treatment outcomes and patient safety, including:

• Liver disease: Individuals with liver disease should exercise caution when using Uratuf since it can compromise liver function and increase the likelihood of adverse effects.
• Kidney disease: Renal impairment may influence how the medication is metabolized and excreted, necessitating close monitoring and possible dosage modifications.
• Active infections: Using Uratuf in individuals with active infections might complicate therapy because the medicine may further depress the immune system.
• Blood disorders: Uratuf may worsen conditions like Anemia or Thrombocytopenia, increasing the risk of bleeding or exhaustion.
• Cardiovascular conditions: Patients with heart problems should exercise caution since chemotherapy could worsen pre-existing cardiovascular disorders.

Food interactions 

The following food interactions need to be considered while having these capsules:

• Alcohol: Avoid consuming alcohol since it may enhance the probability of side effects and adversely affect liver function.
• High-fat meal: Having high-fat meals can interfere with the absorption of Tegafur, potentially reducing its effectiveness. 

Precautions

When using Uratuf 100/224 mg capsules, the following precautions should be observed to ensure safety and efficacy:

• Do not take the capsules if you are allergic to Tegafur or Uracil.
• Inform your doctor about any significant health conditions, especially liver or kidney issues, since dose modifications may be required.
• Uratuf should not be used if you are pregnant, intending to conceive, or breastfeeding because of the potential hazards to the fetus or infant.
• Uratuf may induce dizziness or impaired vision, so avoid driving or operating heavy machinery after consuming it.
• Schedule frequent follow-ups with your healthcare provider to assess your reaction to therapy and change doses as needed.

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FAQs

Does Uratuf 100mg/224mg Capsule affect fertility?

Uratuf tablets may impair fertility. Treatment with this medicine may result in temporary infertility, so address any fertility issues with your healthcare medical professional before beginning therapy to avoid any complications.

How long is the normal Uratuf treatment cycle?

The treatment cycle of Uratuf capsules typically lasts 28 days, followed by a 7-day break, after which it can be repeated as prescribed by a healthcare expert. For further guidance contact your doctor.

What should I do if I am experiencing severe side effects?

If you suffer severe side effects such as persistent nausea, vomiting, or symptoms of infection (fever, chills), call your doctor right away for advice and recommended changes to your treatment regimen.

If I miss a dosage of Uratuf, what should I do?

If you forget a dosage, take it as soon as you recall. If it is near to your next scheduled dosage, skip the missed dose and begin your usual schedule. Don't double the dosage.

What are the long-term consequences of using Uratuf?

Long-term usage of Uratuf capsules may lead to some complications, like reduced blood cell count and raising the risk of infection. Hence, close monitoring and frequent blood tests are required during therapy.