Lucrin Depot 11.25 Mg Injection

Medically Reviewed by

Dr. Akanksha Kaushal

Dr. Akanksha, Pharm-D

Dr. Akansha is a licensed Clinical Pharmacologist with extensive expertise in pharmacovigilance, prescription analysis, drug information, and safety. She's a dedicated educator and avid learner. Dr. Akansha also reviews medical content on GoodRxMedicine, ensuring accurate pharmaceutical information is accessible to all.

Written by

Julian Carter

Julian Carter

Julian, an MBA in Pharmaceutical Management, brings a dynamic blend of expertise and impact with his contributions at GoodRxMedicine. His dedication and innovative spirit continue to shape a brighter future in pharmaceutical management.

What is Lucrin Depot 11.25?

Lucrin Depot 11.25 mg includes Leuprolide Acetate, a Gonadotropin-releasing Hormone (GnRH) agonist used to treat hormone-sensitive diseases, including advanced Prostate Cancer, Endometriosis, and Uterine Fibroids. 

It boosts hormone synthesis initially but eventually leads to testosterone suppression in men and Estrogen in women. This suppression helps to control symptoms linked with these disorders.

Abbott Healthcare India manufactures this injection.

Uses of Lucrin Depot 11.25

Lucrin Depot 11.25 mg is a GnRH agonist used to treat various medical disorders, including:

• It is primarily used as hormonal therapy for Prostate Cancer, where it lowers testosterone levels and slows Cancer development.
• It is also used to treat Endometriosis and Uterine Fibroids by lowering Estrogen levels, which relieves symptoms such as pelvic discomfort and excessive bleeding.
• It also cures precocious puberty (early puberty) in youngsters by postponing hormonal changes.
• In rare circumstances, it is employed in assisted reproductive technologies like in-vitro fertilization. 

Working and benefits of Leuprolide

Leuprolide is a Gonadotropin-releasing Hormone (GnRH) agonist that controls hormone levels by first stimulating and then suppressing the synthesis of Luteinizing Hormone (LH) and Follicle-stimulating Hormone (FSH) from the pituitary gland.  

This results in a considerable fall in testosterone levels in males and Estrogen levels in women, making it appropriate for hormone-sensitive disorders.

Common benefits of Leuprolide include:

• It is frequently employed in Prostate Cancer treatment to decrease testosterone levels and delay disease development.
• It helps women manage Endometriosis and Uterine Fibroids by lowering Estrogen levels, which relieves symptoms like discomfort and heavy bleeding.
• Leuprolide is also used to treat precocious puberty, which delays puberty in children by reducing hormone production.
• It is also used in assisted reproductive therapies to regulate ovulation timing. 
• According to certain research, it can be used to treat hormone-sensitive breast Cancer and Polycystic Ovary Syndrome (PCOS).

However, it is best to consult your healthcare provider before beginning treatment to ensure proper dosage and effectiveness.

Dosage and how to take Lucrin Depot 11.25

Always carefully follow your doctor's recommendations to achieve the most significant outcomes and avoid side effects. Common guidelines are:

• Lucrin Depot11.25 mg is an intramuscular (IM) injection that should only be administered by a doctor or certified nurse in a clinic or hospital.
• Usually injected into the buttocks, thighs, or upper arms. The site may change to avoid discomfort.
• Do not self-administer.
• Your healthcare provider will decide the appropriate dose and frequency. 

Side effects

Some people might face moderate side effects that do not require any medical aid and subside as their bodies adjust to the medicine. Possible side effects include: 

• Reduced libido
• Fatigue
• Muscle weakness
• Erectile Dysfunction
• Excessive sweating

If any of these become troublesome or persistent, seek medical attention immediately.

Interactions

Like any medication, Lucrin Depot 11.25 injection​ may interact with other medicines, pre-existing health conditions, or specific foods.

Drug Interactions

Lucrin Depot 11.25 mg​ may interact with medications, reducing its efficacy or increasing the chances of adverse reactions. Here are some key drug interactions to be aware of:

• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
• Antidepressants
• Diabetes medicines
• Anti-seizure medications
• Anticonvulsants

This is not a complete list. Contact your doctor to rule out any possible drug interactions before using this injection.

Disease Interactions

Lucrin Depot may interact with the following medical conditions, necessitating precautions or dosage modifications. 

• Heart conditions: Lucrin Depot may raise the likelihood of high blood pressure, heart attacks, and stroke, specifically in elderly individuals or those with pre-existing cardiovascular disorders. Patients having a history of Arrhythmias (irregular heartbeats) require constant monitoring.
• Diabetes: Lucrin Depot may impair glucose metabolism, worsening Diabetes or raising the risk of high blood sugar (Hyperglycemia). Patients with pre-existing Diabetes should periodically check their blood sugar levels.
• Seizure disorders neurological conditions: Patients with a history of seizures, brain tumors, or stroke should use Lucrin Depot with care.
• Liver disorder: Lucrin is processed in the liver; thus, individuals with liver impairment may need dosage changes or regular liver function monitoring.

Food Interactions 

No serious dietary interactions have been recorded with Lucrin Depot injections. However, it's essential to look at a few basic points:

• Alcohol: Alcohol intake should be limited or avoided since it might increase adverse effects, including dizziness and exhaustion.
• Calcium & Vitamin D: Dietary calcium and Vitamin D consumption may be increased to promote bone health.

Precautions

Here are some crucial considerations to take while using Lucrin Depot injection:

• If you are pregnant, planning to become pregnant, or breastfeeding, contact your doctor first since Lucrin Depot is not suggested in these conditions.
• Long-term usage may cause reduced bone mineral density. Discuss the possible risk factors of Osteoporosis with your doctor.
• Report any abrupt visual changes or headaches since they may signal significant side effects that need quick treatment.
• Individuals with a background of Depression or other mental health issues should be continuously observed since Lucrin may worsen these conditions.
• Follow your doctor's guidance and attend all follow-up appointments to ensure your safety and effectiveness.

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FAQs

How should Lucrin Depot 11.25 mg Injection be stored?

Lucrin Depot injection should be stored refrigerated between 2°C and 8°C. Keep it in its original box away from direct light and moisture. Don't freeze the injection. Discard any unused medicine. 

Can Lucrin Depot 11.25mg be used as a fertility treatment?

Yes, Lucrin Depot is occasionally used in Assisted Reproductive Technologies (ART), including in vitro fertilization (IVF). It inhibits ovulation to manage the timing of hormone treatment, preparing the ovaries and uterus for pregnancy.

What happens if I miss a dosage of Lucrin injection?

If a medication is missed, consult your healthcare practitioner to determine when to deliver the next dose. Do not double the dosage. Regular dosage is required to sustain good therapy.

Can I discontinue Lucrin medication suddenly?

No. Stopping Lucrin suddenly might cause symptoms to worsen or create a hormonal imbalance. Always check with your doctor before stopping therapy to decide the best course of action.

Can Lucrin be used with children?

Yes. Lucrin Depot is usually used in adults for diseases such as Prostate Cancer, Endometriosis, and Fibroids, but it may also be used in children for precocious puberty (early puberty). However, a healthcare professional should carefully supervise its usage in children.