Kabidarba 40 Injection

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Dr. Akanksha Kaushal

Dr. Akanksha, Pharm-D

Dr. Akansha is a licensed Clinical Pharmacologist with extensive expertise in pharmacovigilance, prescription analysis, drug information, and safety. She's a dedicated educator and avid learner. Dr. Akansha also reviews medical content on GoodRxMedicine, ensuring accurate pharmaceutical information is accessible to all.

Written by

Julian Carter

Julian Carter

Julian, an MBA in Pharmaceutical Management, brings a dynamic blend of expertise and impact with his contributions at GoodRxMedicine. His dedication and innovative spirit continue to shape a brighter future in pharmaceutical management.

What is Kabidarba 40?

Kabidarba 40 is a prescription Anemia injection that contains 40 micrograms of Darbepoetin Alfa, a synthetic type of Erythropoietin. It is an Erythropoiesis-stimulating Agent (ESA) that is used to treat Anemia induced by Chronic Kidney Disease (CKD) and chemotherapy. 

It encourages bone marrow to create more red blood cells, boosting oxygen transport throughout the body and relieving symptoms of Anemia. Renowned pharma firm Fresenius Kabi India Pvt. Ltd. manufactures this injection.

Uses of Kabidarba 40

Kabidarba 40 has several applications, including:

• Managing Anemia in adults and children with Chronic Kidney Disease.
• Treating Anemia in adult Cancer patients receiving chemotherapy.
• Stimulating red blood cell production to increase oxygen supply throughout the body.
• Helping to lessen the need for blood transfusions in individuals with Anemia.
• Managing symptoms of fatigue or weakness caused by Anemia in individuals with kidney problems or Cancer.

Working and benefits of Darbepoetin Alfa

Darbepoetin Alfa in Kabidarba 40 is an artificial form of Erythropoietin, a hormone that the kidneys naturally produce to stimulate red blood cell synthesis in the bone marrow. It attaches to Erythropoietin receptors in the bone marrow, triggering the generation and release of red blood cells into the circulation. 

This helps to treat Anemia, especially in individuals with CKD or those receiving chemotherapy.

Benefits of Darbepoetin Alfa for Anemia due to CKD and chemotherapy include:

• Reduces anemia symptoms: Increases red blood cell formation, which helps to relieve anemia symptoms, such as fatigue, weakness, and dizziness.
• Improves quality of life: Darbepoetin Alfa enhances the quality of life by raising red blood cell counts, which allows patients to be more active.
• Reduces the need for blood transfusions: It helps to lessen the frequency of blood transfusions in individuals with CKD or those receiving chemotherapy.
• Helps manage chemotherapy-induced Anemia: Helps manage chemotherapy-induced anemia, improving tolerance to treatment.
• Enhances oxygen transport: By increasing red blood cell synthesis, it improves oxygen transport throughout the body, which benefits general health and performance.

Dosage and how to take Kabidarba 40

Here are some general usage instructions for Kabidarba 40 injection:

• A certified healthcare practitioner administers Kabidarba 40 injections in a clinic or hospital setting.
• The injection can be given either subcutaneously (under the skin) or intravenously (into a vein).
• Avoid self-administering the injection.
• The doctor determines the dose and frequency by the patient's health, hemoglobin level, and reaction to therapy.

Side effects

Kabidarba injection can lead to some potential side effects, including:

• Stomach pain
• High Blood Pressure
• Rash
• Pain at the injection site
• Cough

These side effects are usually mild and short-lived, often subsiding as your body adapts to the medication. However, if they persist or become more severe, seeking medical advice promptly is essential to ensure proper management and timely intervention.

Interactions

Certain medicines, medical conditions, and dietary choices may interact with the Kabidarba 40 injection, reducing its effectiveness and potentially increasing the risk of unwanted side effects.

Drug interactions

Kabidarba 40 may interact with medications, potentially reducing its efficacy or raising the risk of adverse effects. Common medication interactions include:

• Blood thinners
• Immunosuppressants
• ACE Inhibitors
• Iron Supplements
• Erythropoiesis Boosters
• Chemotherapy medicines

The medications listed above are not the only ones that may interact with Kabidarba. Consult your doctor for personalized advice and a complete assessment of potential interactions.

Disease interactions

Some potential disease interactions of this injection include:

• Hypertension (High Blood Pressure): Kabidarba 40 can worsen or result in High Blood Pressure. The patient's Blood Pressure should be examined regularly.
• Cardiovascular disease: The injection can increase the risk of heart attacks, strokes, and blood clots, particularly in people with previous heart disorders.
• Seizure disorders:  The injection may raise the risk of seizures and necessitate constant monitoring in vulnerable individuals.
• Cancer: The medication may reduce survival time or speed up tumor growth in certain Cancer patients.
• Pure Red Cell Aplasia (PRCA): The injection can trigger or worsen PRCA, a rare disorder in which the body stops manufacturing red blood cells.
• Liver disease: Patients with liver problems should use this injection cautiously.

Food interactions

Kabidarba 40 has no significant dietary interactions. However, it is critical to maintain a well-balanced diet while taking this medication. 

Precautions

When using Kabidarba 40, take the following precautions to reduce the probability of side effects:

• Regular Blood Pressure monitoring is essential.
• The medication is not meant to be used by pregnant or breastfeeding females.
• To avoid overproduction of red blood cells, hemoglobin levels must be checked often.
• If you get a rash, swelling, or trouble breathing, discontinue using the medication and seek medical attention.
• Maintain appropriate iron levels as directed by your doctor for optimal therapy.
• To avoid complications, always take it as directed by a physician.

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FAQs

Can Kabidarba be used to treat Anemia that is not caused by kidney failure or chemotherapy?

No. Kabidarba is particularly authorized for Anemia caused by Chronic Kidney Disease and chemotherapy. It is not suggested for use in other types of Anemia like iron deficiency Anemia, unless prescribed by a doctor.

Does Kabidarba injection influence diabetics' blood sugar levels?

Yes. While Kabidarba has no direct effect on blood sugar, it may raise Blood Pressure, which can be a problem for people with Diabetes. Frequent monitoring of Blood Pressure and glucose levels is recommended.

Does Kabidarba 40 injections induce weight gain?

No. This injection does not induce weight gain. However, it may cause fluid retention, making you feel bloated or heavy. If you notice significant weight fluctuations, visit your healthcare provider.

Does Kabidarba 40 induce blood clots?

Yes, it can raise the risk of blood clots, particularly if hemoglobin levels rise too fast. Patients with a history of clotting issues should proceed with care while using this injection.

How should Kabidarba be stored?

Kabidarba injection should be kept in the fridge at 2-8°C (not frozen). It can be stored at room temperature for a short time if necessary but should be used immediately.