Instgra 50 Mg Tablet

Medically Reviewed by

Dr. Akanksha Kaushal

Dr. Akanksha, Pharm-D

Dr. Akansha is a licensed Clinical Pharmacologist with extensive expertise in pharmacovigilance, prescription analysis, drug information, and safety. She's a dedicated educator and avid learner. Dr. Akansha also reviews medical content on GoodRxMedicine, ensuring accurate pharmaceutical information is accessible to all.

Written by

Julian Carter

Julian Carter

Julian, an MBA in Pharmaceutical Management, brings a dynamic blend of expertise and impact with his contributions at GoodRxMedicine. His dedication and innovative spirit continue to shape a brighter future in pharmaceutical management.

What is Instgra 50 mg

Instgra 50 mg tablet is an Antiretroviral medication containing Dolutegravir, which belongs to the Integrase Strand Transfer Inhibitors (INSTIs) class.

It is used to manage Human Immunodeficiency Virus (HIV) infection. It does not cure HIV, but it helps reduce the virus's amount in the body and increases CD4 cell count (white blood cells).

Instgra 50 mg is widely manufactured and marketed by Emcure Pharmaceuticals Ltd.

Uses of Instgra 50 mg

Instgra 50 mg tablet contains Dolutegravir and treats HIV/AIDS infection in adults and children weighing at least 14 kg. It helps control the growth of the disease and improve the immune system, lowering the chances of getting complications, such as new infections and certain cancers.

Instgra is not a cure for HIV or AIDS but helps to control the virus, preventing it from multiplying and reducing the risk of AIDS. By decreasing the viral load, Instgra boosts the immunity of affected individuals.

Working and benefits of Dolutegravir

Dolutegravir is an antiviral medication used with other medicines to treat HIV-1 infections. It can also be used as part of post-exposure Prophylaxis to prevent HIV infection after potential exposure.

Working:

Dolutegravir works by blocking HIV integrase, an enzyme that the virus needs to replicate. By binding to the active site of the integrase, Dolutegravir prevents the transfer of viral DNA into the host cell's DNA, which is a critical step in the HIV replication cycle. This action inhibits the virus from growing and infecting more cells.

Benefits:

• Reduces viral load: Dolutegravir minimizes the amount of virus in the body.
• Increases CD4 cell count: It increases the number of CD4 cells (white blood cells) in the blood, helping the body fight infection.
• Once-daily dosing: Its Pharmacokinetic properties allow for once-daily dosing, with or without food.
• Minimal drug interactions: Dolutegravir has a low potential for drug interactions.
• Well-tolerated: Dolutegravir's effect is not similar to that in human host cells, giving it excellent tolerability and minimal toxicity.
• Good distribution: Dolutegravir distributes well in Cerebrospinal Fluid and reaches effective concentrations in the male and female genital tracts.
• No impact on Renal function
• Rapid absorption: Dolutegravir is rapidly absorbed, achieving maximal blood concentration hours after ingestion.
• The World Health Organization (WHO) recommends it as a first- and second-line treatment for all persons with HIV.

Dosage and how to take Instgra 50 mg

Instgra 50 mg is prescription-based and should be taken as per a healthcare professional's instructions.

However, you can follow a few steps to increase the effectiveness of this medication:

• Instgra can be taken with or without food. When Instgra is taken twice daily, your doctor may advise you to take it with food. It should not be taken alone and must be combined with other antiretrovirals.
• Do not chew, break, or crush the medication. Swallow the tablet whole with a full glass of water.
• If you miss a dose and notice within 8 hours, take the missed dosage with food. If it is more than 8 hours, skip the dosage and take the next dose as usual. Don’t take a double dose for the missed dose.
• Do not stop taking the medication without your physician’s approval. Don’t exceed the recommended dosage. Strictly follow the prescribed amount of dosage.

Side effects

Like any medication, Instgra 50 mg may cause some side effects. These adverse effects are temporary and will subside as your body adjusts.

However, consult a healthcare professional if the side effects persist or worsen.

The side effects of using Instgra 50 are as follows:

• Diarrhea
• Nausea and vomiting

• Rash
• Itching
• Stomach discomfort
• Dizziness
• Tiredness (fatigue)

Interactions

Like most medications, Instgra 50 may interact with other medicines you take, your health conditions, or specific foods or drinks.

Drug interactions

The below-listed medicines listed might affect the effectiveness when taken along with Instgra 50:

• Antacids: Do not take antacids to treat indigestion and heartburn for 6 hours before or at least 2 hours after taking Instgra.
• Calcium, iron supplements, and multivitamins: Avoid taking these supplements for at least 2 hours before or 6 hours after taking Instgra.
• Metformin: Instgra can increase metformin concentrations, potentially requiring a dose adjustment of metformin to maintain glycemic control.
• Etravirine, efavirenz, fosamprenavir/ritonavir, nevirapine, or tipranavir/ritonavir: Used to treat HIV infection, these medications may interact with Instgra.
• Phenytoin, phenobarbital, oxcarbazepine, and carbamazepine: Used to treat epilepsy or bipolar disorder, these medications may interact with Instgra.
• St. John’s wort: A herbal remedy for depression, it may interact with Instgra.
• Fampridine and Dofetilide: Do not take an Instgra tablet if you take Fampridine (used in multiple Sclerosis) or Dofetilide (used to treat heart conditions).

Disease interactions

Instgra 50 has notable interactions with various medical conditions:

• Liver problems: Since the liver metabolizes Instgra, individuals with severe Hepatic Impairment should avoid it.
• Kidney disease: Use with caution in severe kidney diseases.
• Cardiac disorders: Use with caution in heart failure.
• Respiratory disorders: Use with caution in respiratory distress.
• Blood disorders: Use with caution in Anemia and Thrombocytopenia
• Diabetes: Instgra can increase glucose levels in patients.
• Bone Problems: Instgra may cause joint pain, bone problems, and stiffness.
• Mental Health Conditions: Patients with a history of suicidal thoughts and behaviors or depression should exercise caution.
• Opportunistic infections: Dolutegravir does not cure HIV, and patients may still develop opportunistic infections and other complications.

Consult your doctor before taking Instgra 50 if you have any of these conditions to prevent potential health risks.

Food interactions

Food choices can impact how effective Instgra 50 mg is for a user. Keep these points in mind:

• Oil-rich/spicy foods, sugary snacks, and drinks: When taking the Instgra tablet, consider sticking to simple meals and avoid eating oil-rich/spicy foods, sugary snacks, and beverages.
• Alcohol: Instgra 50 mg tablet generally causes fatigue. Thus, it is advised not to be taken with alcohol.

Always consult your doctor before combining Instgra 50 with other drugs or dietary items.

Precautions

Before starting Instgra 50 mg, it is essential to consider the following:

• Allergies: Do not take Instgra 50 mg tablet if you are allergic to Dolutegravir or its ingredients.
• Pregnancy and breastfeeding: It is not advised during pregnancy due to the risk of toxicity to the fetus and malformation. Breastfeeding is also not recommended, as the medicine may pass through breast milk.
• Driving and operating machinery: Use caution while driving or operating heavy machinery, as Instgra 50 mg tablet may cause fatigue.
• Adherence: Do not overdose on this medicine or stop taking it without consulting your physician.

Following these precautions assures the patients of the benefits and minimal negative impacts of Instgra under medical supervision.

Why buy from us

Purchasing Instgra 50 from GoodRxMedicine, you enjoy advantages such as

• Special discounts and affordable pricing
• Secure and private packaging to maintain your privacy
• 24/7 customer service to assist with inquiries
• Access to substitute medications with the same active ingredients

FAQs

Can I take Antacids or multivitamins with an Instgra tablet?

No, you should not take Antacids or multivitamins within 2 hours before or 6 hours after taking Instgra tablets. This timing is crucial to ensuring proper absorption and effectiveness of the medication. Always consult your doctor for personalized advice.

Does Instgra tablet cause Osteonecrosis?

Yes, Instgra tablets containing Dolutegravir may increase the risk of Osteonecrosis, particularly when combined with alcohol consumption. According to the clinical report, some individuals on HIV therapy have reported developing this condition. Always consult a healthcare professional for guidance.

What if I have taken an overdose of Instgra tablets?

If you suspect an overdose of Instgra tablets, seek immediate medical attention. Overdosing symptoms may include nausea, vomiting, severe stomach pain, dizziness, or confusion. Do not attempt to force vomiting unless instructed by a healthcare professional.

How long does Instgra 50 take to be effective?

Instgra 50 typically is effective within 2 to 4 weeks of starting treatment. It manages HIV-1 infection by reducing the viral load and improving the immune system. Depending on the prescription, it can be taken with or without food as your physician prescribes to maximize its effectiveness.

Can Instgra 50 mg cause any long-term side effects?

Yes, Instgra 50 can cause long-term side effects such as liver problems, weight gain, and increased cholesterol. Mental health issues may also arise. Long-term use requires caution during pregnancy and in individuals with pre-existing conditions.