Epofer 6000 IU/ml Injection

Medically Reviewed by

Dr. Akanksha Kaushal

Dr. Akanksha, Pharm-D

Dr. Akansha is a licensed Clinical Pharmacologist with extensive expertise in pharmacovigilance, prescription analysis, drug information, and safety. She's a dedicated educator and avid learner. Dr. Akansha also reviews medical content on GoodRxMedicine, ensuring accurate pharmaceutical information is accessible to all.

Written by

Julian Carter

Julian Carter

Julian, an MBA in Pharmaceutical Management, brings a dynamic blend of expertise and impact with his contributions at GoodRxMedicine. His dedication and innovative spirit continue to shape a brighter future in pharmaceutical management.

What is Epofer 6000 IU/ml?

Epofer 6000IUl/ml is a recombinant human erythropoietin medication designed to treat anemia associated with chronic kidney disease, chemotherapy, and other medical conditions. It works by promoting red blood cell production. Emcure Pharmaceuticals Ltd manufactures this injection. 

The active ingredient, also known as Epoetin Alfa, belongs to the Erythropoiesis-stimulating Agents (ESAs) class. 

Uses of Epofer 6000 IU/ml

Epofer is primarily used to manage anemia in multiple clinical scenarios:

• Treatment of anemia in individuals with chronic kidney disease. 
• Management of chemotherapy-related anemia. 
• Improve HIV treatment-related anemia.
• Reduction of blood transfusion requirements. 
• Improvement of hemoglobin levels in patients with renal insufficiency. 
• Support for patients undergoing surgical procedures with anticipated blood loss. 

Working and benefits of Epoetin Alfa

Epofer works by mimicking natural Erythropoietin, a hormone that stimulates the bone marrow to produce red blood cells. It binds to specific receptors on erythroid progenitor cells, promoting their proliferation and differentiation into mature red blood cells. 

This action increases hemoglobin levels and improves oxygen delivery to tissues, which is particularly beneficial in people with anemia induced by chronic kidney disease, chemotherapy, or certain chronic conditions. 

Epofer enhances the overall quality of life by reducing fatigue and improving exercise tolerance while also minimizing the need for blood transfusions in appropriate clinical settings.

Key benefits include:

• Increased red blood cell production
• Improved oxygen-carrying capacity
• Reduced need for blood transfusions
• Enhanced energy levels
• Better quality of life for patients
• Minimized complications of chronic anemia

Dosage and how to take Epofer 6000 IU/ml

Epofer injection is administered by a medical professional. The following guidelines are followed:

• Typically given 1-3 times weekly. 
• Administered via subcutaneous or intravenous injection. 
• Dosage is determined by healthcare professionals based on individual patient needs. 
• Do not self-administer. 

Side effects

Common Epofer side effects include:

• Headache
• Fatigue
• Injection site pain
• Cough
• Mild fever
• Blood pressure changes
• Potential blood clot risk

Most side effects are mild and manageable under medical supervision.

Interactions

Epofer injection may interact with medicines, food, and diseases:

Drug Interactions

May interact with:

• Immunosuppressants
• Chemotherapy medications
• Blood pressure medications
• Antibiotics
• Anticoagulants

Disease Interactions

Use caution with:

• Uncontrolled Hypertension: Epoetin Alfa can increase blood pressure due to its role in stimulating red blood cell production, increasing blood viscosity. In patients with uncontrolled Hypertension, this can exacerbate their condition and increase the risk of cardiovascular events.
• Active Cancer: Epoetin alfa may promote tumor progression or recurrence in certain Cancers, particularly if administered to patients with active malignancies that are not receiving chemotherapy. The drug stimulates erythropoiesis, which can inadvertently support the growth of Cancer cells.
• Severe liver disease: People with severe liver problems can have altered metabolism and excretion of drugs, including Epofer. Additionally, liver dysfunction can lead to anemia, complicating the treatment approach.
• History of blood clots: Epoetin alfa is associated with an increased risk of thromboembolic events, like deep vein thrombosis (DVT) or pulmonary embolism (PE), especially in patients with a history of blood clots. This risk is particularly significant when hemoglobin levels are raised too quickly or to levels above target.

Food Interactions

There are no known significant food interactions. However, avoid alcohol due to a lack of safety information.

Precautions

When using Epofer, consider the following points:

• Monitor blood pressure regularly. 
• Regular hemoglobin and iron level checks. 
• It is not recommended for people with uncontrolled hypertension. 
• Inform the doctor about all medications. 
• Potential increased cardiovascular risk. 
• Pregnancy and breastfeeding require medical consultation. 

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FAQs

Can I stop receiving Epofer 6000IU injection once my symptoms subside?

No, do not stop Epoetin Alfa treatment without medical consultation, even when you feel better. Abrupt discontinuation can cause anemia to recur. The healthcare provider will determine the required duration and tapering of treatment.

Can I use Epofer 6000IU injection during pregnancy?

No, Epofer is generally unsafe during pregnancy. Consult your healthcare provider. Epofer should only be used during pregnancy if the potential benefits outweigh the potential risks. Medical supervision is crucial.

Is Epofer 6000IU injection safe?

Epofer is generally safe when administered under medical supervision. However, a healthcare professional must carefully evaluate potential side effects and individual health conditions. They will also determine the required safe dosage for treatment.

How Epofer 6000IU injection is administered?

It is administered via subcutaneous (under the skin) or intravenous (into the vein) injection by trained healthcare professionals. Dosage and frequency depend on individual patient requirements and underlying medical conditions.

What are the long-term effects of using Epofer 6000IU injection?

Long-term use of Epofer 6000IU injection may have potential cardiovascular risks. Consistent monitoring of blood pressure, kidney function, and blood parameters is essential to mitigate potential complications. Inform your doctor about your medicines and medical history to ensure safety.