Derise 100 Pre-filled Syringe

Medically Reviewed by

Dr. Akanksha Kaushal

Dr. Akanksha, Pharm-D

Dr. Akansha is a licensed Clinical Pharmacologist with extensive expertise in pharmacovigilance, prescription analysis, drug information, and safety. She's a dedicated educator and avid learner. Dr. Akansha also reviews medical content on GoodRxMedicine, ensuring accurate pharmaceutical information is accessible to all.

Written by

Julian Carter

Julian Carter

Julian, an MBA in Pharmaceutical Management, brings a dynamic blend of expertise and impact with his contributions at GoodRxMedicine. His dedication and innovative spirit continue to shape a brighter future in pharmaceutical management.

What is Derise 100 Pre-filled Syringe?

Derise 100 Pre-filled Syringe is a medicine used to treat anemia due to Chronic Kidney Disease (CKD) and chemotherapy. It contains Darbepoetin alfa, an Erythropoiesis-stimulating medication. 

Darbepoetin alfa stimulates red blood cell production, which regulates hemoglobin levels and relieves Anemia symptoms like fatigue and weakness. Derise is administered via injection and requires close monitoring by healthcare experts due to potential adverse effects such as Hypertension (elevated blood pressure) and injection site reactions.

The syringe is manufactured by a trusted pharma company, Hetero Drugs Ltd.

Uses of Derise 100 Pre-filled Syringe

Derise 100 Pre-filled Syringe uses include:

• It reduces the need for blood transfusions and aids in managing Anemia due to cancer chemotherapy.
• Contains Erythropoietin, which stimulates the bone marrow to create more red blood cells.
• Boost oxygen supply.
• Supports overall energy levels.
• Improves quality of life in anemic patients.
• The goal is to restore normal hemoglobin levels in people with Anemia due to CKD or chemotherapy.

Working and benefits of Darbepoetin alfa

Darbepoetin alfa in Derise 100 Pre-filled Syringe is a synthetic version of the hormone Erythropoietin, which promotes red blood cell formation in the bone marrow. It is used to treat Anemia due to Chronic Kidney Disease (CKD) or chemotherapy. In CKD, the kidneys produce less Erythropoietin, resulting in lower red blood cell formation. 

Chemotherapy can also lower the red blood cell count. Darbepoetin alfa works by replicating the activity of natural Erythropoietin. This, in turn, stimulates the synthesis of red blood cells, increasing hemoglobin levels and decreasing the need for blood transfusions. 

Darbepoetin, being effective in treating Anemia induced by CKD and chemotherapy, has the following benefits:

• Increases red blood cell production: It stimulates the bone marrow to create more red blood cells, treating the root cause of Anemia.
• Improves hemoglobin levels: Helps to boost hemoglobin levels, lowering Anemia symptoms, including weariness and weakness.
• Reduces the need for blood transfusions: Patients with CKD or receiving chemotherapy require fewer blood transfusions.
• Well-tolerated: It is generally well tolerated and has controllable side effects, making it appropriate for long-term usage in chronic diseases.
• Enhances quality of life: Relieving Anemia symptoms can considerably improve patients' general quality of life and capacity to participate in everyday activities.

Dosage and how to take Derise 100 Pre-filled Syringe

Some general usage instructions for Derise include:

• Derise should be administered subcutaneously (under the skin) by a trained nurse or doctor in a hospital or clinical setting.
• Before administering the injection, clean the site with alcohol. Inject the entire dosage gently into the fatty tissue of the thigh, belly, or upper arm.
• Before injecting, do not shake the syringe; instead, look for visible particles or discoloration.
• Typically given once a week. However, consult your doctor for proper dosage and frequency guidance.

Side effects

Common side effects of Derise 100 Pre-filled Syringe are:

• Rash
• Abdominal pain
• Pain at the injection site
• Cough
• High blood pressure

While most side effects of the medication are mild and improve as your body adjusts to the medication, it's essential to contact your healthcare provider if they persist or become more severe. 

Interactions

Derise can interact with various medications, health conditions, and even certain foods, potentially altering how well it works or increasing the risk of side effects.

Drug interactions

Patients with Anemia caused by CKD or chemotherapy should be cautious about other medications that can overlap with Derise. Here are some common drug interactions:

• ACE inhibitors
• Other Erythropoiesis-stimulating agents
• Anticoagulants
• Iron supplements
• Blood pressure medicines

This list doesn't cover all the medications that might interact with the Derise 100 Pre-filled Syringe. To ensure safe and effective use, it's essential to speak with your doctor or healthcare provider for a more thorough understanding and personalized advice.

Disease interactions

Consider the following disease interactions while using the medication to ensure safety and effectiveness:

• Kidney disease: Although no interaction has been established, close monitoring is required for patients with severe kidney impairment.
• Liver disease: Caution is advised for liver patients. Dose adjustments may be required.
• Diabetes:  Diabetic patients with kidney disease should use this medication cautiously after consulting their doctor.
• Cancer: Derise can induce an increased risk of tumor progression; hence, its usage is frequently limited or closely monitored in cancer patients.
• Thrombosis: Using Derise raises the risk of Thrombosis (blood clots), especially in chemotherapy patients, necessitating close monitoring.

Food interactions

No significant interactions have been established between Derise 100 Pre-filled Syring. Consult your doctor before considering the medication to reduce the probability of any unwanted reactions.

Precautions

Take a few precautions to guarantee safe and efficient treatment with the Derise 100 Pre-filled Syringe. Here are the primary considerations:

• Inform your doctor of any current medical issues, particularly heart disease, high blood pressure, or a history of seizures or strokes.
• Blood tests may be performed to check electrolyte levels (such as potassium), hemoglobin, and total blood cell count.
• If you are pregnant, intend to become pregnant, or are breastfeeding, you must consult your doctor. Derise's safety during these periods has not been thoroughly established.
• Do not self-administer the medication.

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FAQs

Can Derise 100 Pre-filled Syringe be used in children?

Yes. The medication can be used in children, especially those who have Anemia caused by CKD or chemotherapy. However, dose and safety should be carefully monitored under medical supervision, with regular assessments.

Can Derise be used to treat Anemia in people without CKD?

No. Derise 100 is specially designed to treat Anemia caused by CKD and chemotherapy. It is not usually suggested for use in individuals who do not have these diseases since its efficacy and safety in other kinds of Anemia have not been well investigated. 

What should I do if I miss a dosage of Derise 100?

If you miss a dosage of Derise 100 Pre-filled Syringe, take it as soon as you recall, unless it is nearing the time of your next scheduled dose. Don't increase the dose to compensate for the missing one. If you are unsure, consult your healthcare professional for advice.

How long may I use Derise 100 before discontinuing treatment?

The patient's reaction to medication determines the duration of treatment with Derise, the degree of Anemia, and the underlying reason. Your healthcare practitioner will monitor your condition and adjust your treatment plan as needed. Treatment often lasts as long as Anemia needs to be adequately managed.

What should I do if I observe swelling or redness around the injection site?

Subcutaneous injections can cause swelling, redness, or discomfort at the injection site. If these symptoms persist or worsen, consult your doctor for tailored advice to rule out infection or other concerns.