CA ATRA 10 Mg Capsule

Medically Reviewed by

Dr. Akanksha Kaushal

Dr. Akanksha, Pharm-D

Dr. Akansha is a licensed Clinical Pharmacologist with extensive expertise in pharmacovigilance, prescription analysis, drug information, and safety. She's a dedicated educator and avid learner. Dr. Akansha also reviews medical content on GoodRxMedicine, ensuring accurate pharmaceutical information is accessible to all.

Written by

Julian Carter

Julian Carter

Julian, an MBA in Pharmaceutical Management, brings a dynamic blend of expertise and impact with his contributions at GoodRxMedicine. His dedication and innovative spirit continue to shape a brighter future in pharmaceutical management.

What is CA Atra?

CA Atra is an anticancer medication that includes Tretinoin, a vitamin A derivative. It is primarily used for treating Acute Promyelocytic Leukemia (APL), a rare type of Blood Cancer. It works by stimulating the differentiation of immature blood cells into mature ones, limiting Cancer cell growth. 

The medication is frequently used as part of combination therapy to increase treatment efficacy and patient outcomes in controlling this severe blood condition. Jenome Biophar Pvt. Ltd manufactures it.

Uses of CA Atra

CA Atra 10 capsules can be used under the following circumstances:

• Acute Promyelocytic Leukemia Treatment: The capsule causes abnormal cells to differentiate into mature white blood cells, effectively limiting Cancer cell growth in the bone marrow.
• Combination therapy: It is commonly used with chemotherapy medications to improve treatment efficacy and patient outcomes.
• Induction of remission: CA Atra 10 mg has demonstrated significant efficacy in fully recovering APL patients and restoring normal blood cell production.
• Improved survival rates: Incorporating the medication into treatment regimens has been linked to considerably higher long-term survival rates among people with APL.

Working and benefits of Tretinoin

Tretinoin, a Vitamin A derivative, is a potent retinoid therapy for Acute Promyelocytic Leukemia (APL). In APL, abnormal white blood cells known as Promyelocytes accumulate in the bone marrow, blocking normal blood cell synthesis. 

This is caused by a genetic abnormality that prevents immature cells from growing into healthy white blood cells. Tretinoin targets and breaks down this unusual protein, allowing Leukemia cells to develop into normal white blood cells. 

This mechanism helps the body naturally eliminate Cancer cells.

Tretinoin serves the following benefits for APL:

• Unlike chemotherapy, which just kills Cancer cells, Tretinoin addresses the underlying cause of APL.
• When paired with Arsenic Trioxide (ATO) or chemotherapy, it greatly increases survival rates and lowers the chance of recurrence.
• It suppresses the immune system less severely than standard chemotherapy.
• Tretinoin has transformed APL treatment, converting what was considered a lethal illness into one with a promising future when treated early.

Dosage and how to take CA Atra

Always take the medication as directed by your doctor to get the most out of it. Here are common usage guidelines:

• Take the capsule preferably at the same time each day for the maximum benefit.
• Swallow the capsule whole with water. Avoid chewing or crushing it.
• Have the medicine with food to enhance absorption.
• Consult your doctor regarding dosage and frequency of use.

Side effects

When used as directed, these capsules are generally well-tolerated. However, some mild side effects may occur, including:

• Fever
• Headache
• Rash
• Bone pain
• Dry lips

These side effects often do not require medical aid and vanish as your body adjusts to the medication. However, seek medical advice promptly if you experience any persistent or troublesome side effects.

Interactions

CA Atra 10, like other medications, may interact with other prescription and over-the-counter medications, certain foods, and health conditions. 

Drug interactions

The capsule may interact with the following medicines, increasing the risk of potential side effects:

• Antibiotics like Tetracycline
• Fungal medications, including Ketoconazole
• Cimetidine
• Cyclosporine
• Diltiazem
• Erythromycin

This is not the complete list of interacting medicines. Reach out to your doctor for further assistance.

Disease interactions

CA Atra capsules may interact with certain health conditions. Here are some significant disease interactions to consider:

• Liver disease: The capsule is processed in the liver; hence, individuals with liver dysfunction may suffer altered medication metabolism, resulting in higher toxicity or lower effectiveness.
• Kidney disease: There is less evidence available on the safety and efficacy of these capsules in individuals with kidney disorders; thus, caution is suggested.
• Lung conditions: Patients with lung illnesses should consult their doctor since CA Atra may worsen respiratory difficulties.

Always consult a healthcare expert before beginning the therapy, mainly if you have any underlying health issues.

Food interactions 

While no particular dietary interactions have been identified that would impair the efficacy of CA Atra, it is essential to consider the following:

• Retinoids or Vitamin A: Avoid taking it with other retinoids or Vitamin A supplements, as these might cause additional side effects.
• Alcohol: Alcohol intake should be addressed with caution; ask a healthcare practitioner about its safety while using the medication.

Precautions

When using CA Atra capsules to treat APL, take the following precautions:

• Inform your doctor if you are allergic to Tretinoin, peanuts, soya, or other capsule components.
• Avoid driving or using machinery, as this capsule can cause dizziness or severe headaches.
• Use caution if you have a history of liver or kidney illness; consult your doctor about dose changes.
• CA Atra is unsafe during pregnancy since it could harm the baby. However, breastfeeding mothers can use the medication safely after consulting their doctor.

Always follow your healthcare provider's recommendations for safe use.

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FAQs

Does Atra influence fertility in both men and women?

Yes. Atra may affect fertility, especially when taken with chemotherapy. Men may have temporary or permanent sperm count declines, and women may experience irregular menstruation cycles. Fertility preservation alternatives should be considered before therapy.

What are the uncommon side effects of the Atra capsule?

Hypercalcemia (high calcium levels in the blood) is a rare adverse effect of Atra that can develop when combined with certain antifungal medications, such as Posaconazole. Other unusual problems may include differentiation syndrome, marked by fever, respiratory distress, and weight increase.

Can I get cosmetic treatments while using CA Atra capsules?

It is best to consult your doctor before undertaking cosmetic operations while using the capsule. Atra could worsen skin sensitivity and inflammation, which can impede recovery following cosmetic procedures.

How long is the Atragiven?

Atra is usually given for 30 days during the induction phase of treatment for APL. Depending on the patient's reaction and treatment strategy, it may be used as part of consolidation or maintenance therapy.

Is AML curable?

Yes. AML is treatable, especially if diagnosed early and treated rapidly, which may include chemotherapy and stem cell transplants. However, the prognosis varies depending on age, genetic abnormalities, and overall health, making certain patients more difficult to treat successfully.