Augmentin 625 Duo Tablet

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Dr. Akanksha Kaushal

Dr. Akanksha, Pharm-D

Dr. Akansha is a licensed Clinical Pharmacologist with extensive expertise in pharmacovigilance, prescription analysis, drug information, and safety. She's a dedicated educator and avid learner. Dr. Akansha also reviews medical content on GoodRxMedicine, ensuring accurate pharmaceutical information is accessible to all.

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Julian Carter

Julian Carter

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What is Augmentin 625​​​

Augmentin 625​​ is an antibiotic that combines Amoxicillin and Clavulanic acid. This duo combination effectively treats a wide variety of bacterial infections.

It interferes with bacterial cell wall synthesis, effectively killing bacteria and restricting their further regrowth. It is commonly prescribed for conditions such as Sinusitis, Pneumonia, UTI, and skin infections. 

Augmentin 625​​ is widely manufactured and marketed by Glaxo SmithKline Pharmaceuticals Ltd. 

Uses of Augmentin 625​​ 

Augmentin 625​​ is a broad-spectrum antibiotic prescribed for various bacterial infections, including:

• Urinary Tract Infections (UTIs)
• Respiratory tract infections (e.g., Pneumonia and Bronchitis)
• Eye infections
• Bone and Joint Infections
• Skin and soft tissue infections
• Dental Infections
• Ear, nose, and throat infections such as Otitis Media and Sinusitis.

Augmentin manages persistent infections that do not respond to standard treatments. This bacterial infection medicine provides reliable results for patients with challenging infections, especially when other antibiotics prove ineffective.

Working and benefits of Amoxicillin and Clavulanic

Amoxicillin and Clavulanic acid, combined, are widely used antibiotics that treat various bacterial infections. This combination bypasses bacterial resistance mechanisms.

Amoxicillin is a Penicillin-Type antibiotic that blocks the synthesis of bacterial cell walls. It binds to specific proteins (Penicillin-Binding proteins) involved in cell wall construction, ultimately leading to bacterial cell lysis and death.

Clavulanic acid, on the other hand, blocks the beta-lactamase enzyme. It prevents certain bacteria from producing enzymes (beta-lactamases) that would otherwise degrade Amoxicillin, thus preserving its antibacterial activity. By killing these enzymes, Clavulanic acid broadens the spectrum of infections that Amoxicillin can effectively treat, including those triggered by resistant bacterial strains.

Amoxicillin and Clavulanic acid work well together against a variety of infections, including:

• Ear infections: Commonly used for otitis media.
• Respiratory tract infections: Effective against pneumonia and sinusitis.
• Skin and soft tissue infections: Treats cellulitis and animal bites.
• Urinary tract infections: Addresses infections in the urinary system.

This combination is particularly beneficial because it retains effectiveness against bacteria that produce Beta-lactamase, which would typically make Amoxicillin ineffective.

Dosage and how to take Augmentin 625​​

Augmentin 625 mg is prescription-based and should be taken as per a healthcare professional's instructions. 

However, you can follow a few steps to increase the effectiveness of this medication:

• Take one pill orally twice daily, every 12 hours. Follow your doctor's prescribed dosage for proper treatment.
• Do not chew, break, or crush the medication before consumption. Swallow the tablet whole with a glass of water.
• If you miss your dose of Augmentin, take the medication as soon as you notice. On the other hand, omit the skipped dose if your next dose is due about time.  
• Don't take more than the prescribed number of tablets to avoid overdosing.

Side effects

Like any medication, Augmentin 625 ​​mg may cause some side effects. These adverse effects are temporary and will subside as your body adjusts.

However, consult a healthcare professional if the side effects persist or worsen. 

The side effects of using Augmentin 625 ​​mg are as follows: 

• Diarrhea
• Nausea
• Vomiting
• Stomach pain
• Headache
• Skin rash

Interactions

Like most medications, Augmentin 625 mg may interact with other medicines you take, your health conditions, or specific foods or drinks.

Drug interactions

The below-listed medicines listed might affect the effectiveness when taken along with Augmentin 625 mg:

• Probenecid: Decreases renal tubular secretion of Amoxicillin, leading to increased and prolonged blood concentrations. Coadministration is not recommended.
• Oral anticoagulants: Augmentin may delay prothrombin formation time.
• Allopurinol: Concurrent use can increase the incidence of rashes compared to Amoxicillin alone.
• Oral contraceptives: May reduce the effectiveness of combined oral contraceptives due to alterations in intestinal flora.
• Methotrexate: Augmentin may increase Methotrexate levels, raising the risk of side effects associated with Methotrexate.
• Doxycycline and Azithromycin: These antibiotics can interact with Augmentin, although specific interaction details may vary.
• Specific urine glucose tests: High concentrations of Amoxicillin can cause false-positive results in tests like CLINITEST.
• Exercise caution when combined with blood thinners, gout medications, or immunosuppressants.

Disease interactions

Augmentin has notable interactions with various medical conditions:

• Hepatotoxicity: Augmentin can cause liver damage, especially in patients with pre-existing liver conditions. 
• Colitis: Augmentin may lead to Clostridium Difficile-Associated Diarrhea (CDAD), ranging from mild to severe.
• Mononucleosis: These patients may experience an increased risk of rash and other side effects when taking Augmentin.
• Diabetes: Caution is advised as Augmentin can affect blood sugar levels.
• Phenylketonuria (PKU): Patients with PKU should avoid Augmentin since it contains Phenylalanine, which can be harmful to those with this condition.
• Renal dysfunction: Patients with kidney issues may experience an increased risk of side effects, including Interstitial Nephritis and Crystalluria.
• Pregnancy and Breastfeeding: While Augmentin is generally considered safe, it should only be used if prescribed by your doctor due to potential risks to the fetus or baby during pregnancy or lactation.
• Severe Kidney disease: Not recommended for individuals with severe kidney impairment.
• Liver dysfunction: Use cautiously in patients with liver problems.

Food interactions

Food choices can impact how effective Augmentin 625 ​​mg is for a user. Keep these points in mind:

• High-fat meals: High-fat meals may reduce the absorption of Clavulanate Potassium, so it's best to avoid consuming the medicine immediately after a high-fat meal.
• Alcohol interaction: Augmentin 625​​ is not recommended for use with alcohol because of the risk of increased harmful effects. It may also interfere with the effectiveness of the medication.

Precautions

Following these precautions assures the patients of the benefits and minimal negative impacts of Augmentin 625 mg under medical supervision:

• Allergy history: Avoid use if allergic to Penicillin, Cephalosporins, or Beta-Lactam antibiotics.
• Driving and machinery: Causes dizziness or drowsiness. Avoid operating heavy machinery if affected.
• Diarrhea monitoring: Watch for severe diarrhea, which could indicate a Clostridium Difficile infection.

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FAQs

When to take Augmentin before or after food?

Augmentin 625 should be taken at the start of a meal. This timing helps enhance absorption and reduces the risk of gastrointestinal discomfort. Taking it with food can improve its effectiveness and reduce the likelihood of adverse symptoms like nausea or an upset stomach.

When is the best time to take Augmentin?

The best time to take Augmentin 625 is with a meal, which helps reduce the risk of stomach upset and enhances absorption. It's essential to take it at evenly spaced intervals, following your doctor's prescribed schedule.

What happens if you take Augmentin too close together?

Taking Augmentin too closely together can raise the chance of adverse effects such as nausea, vomiting, and diarrhea. Overdose symptoms may also manifest, such as abdominal pain and decreased urination. Always adhere to prescribed dosing intervals to avoid complications.

How quickly does Augmentin work?

Augmentin typically begins to show effects within 1 to 2 hours after administration, as peak serum levels are reached around this time. However, noticeable clinical improvement may take up to 48 hours of consistent dosing.

Are there any dietary restrictions while taking Augmentin 625 duo tablet?

Yes, while taking Augmentin 625 duo tablet, it is advised to avoid alcohol as it may worsen side effects like dizziness and dehydration. Additionally, consult your doctor if you have liver or kidney issues or are pregnant or breastfeeding.