Assurans Injection

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Dr. Akanksha Kaushal

Dr. Akanksha, Pharm-D

Dr. Akansha is a licensed Clinical Pharmacologist with extensive expertise in pharmacovigilance, prescription analysis, drug information, and safety. She's a dedicated educator and avid learner. Dr. Akansha also reviews medical content on GoodRxMedicine, ensuring accurate pharmaceutical information is accessible to all.

Written by

Julian Carter

Julian Carter

Julian, an MBA in Pharmaceutical Management, brings a dynamic blend of expertise and impact with his contributions at GoodRxMedicine. His dedication and innovative spirit continue to shape a brighter future in pharmaceutical management.

What is Assurans Injection

Assurans Injection containing Sildenafil, classified as a Phosphodiesterase Type 5 (PDE5) inhibitor. It primarily manages Pulmonary Arterial Hypertension in adults and treats Erectile Dysfunction in men.

Sildenafil in Assurans reduces blood pressure within the lungs by relaxing the blood vessels, which enhances blood flow and oxygen supply, ultimately improving lung function.

Assurans​​ is widely manufactured and marketed by Cipla Ltd.

Uses of Assurans Injection

Assurans Injection may be considered for patients who are temporarily unable to take oral Sildenafil.

• Pulmonary Arterial Hypertension (PAH): It treats PAH (high blood pressure in the lungs) to improve the ability to exercise and slow clinical worsening. It relaxes the blood vessels, increases blood supply to the lungs, and reduces the heart's workload.
• Improves exercise ability: It helps to improve exercise ability in individuals with PAH.
• Alternative to oral Sildenafil: It is for patients with PAH who are currently prescribed oral Sildenafil but are temporarily unable to take oral medication.
• Erectile Dysfunction (ED): While the Injection form is mainly for PAH, Assurans is also available in tablet form and can be used to treat Erectile Dysfunction.

Working and benefits of Sildenafil

Sildenafil, commonly known as Viagra, is a medication used to treat ED and PAH. It belongs to a class of drugs called PDE5 inhibitors.

• Erectile Dysfunction: Sildenafil inhibits PDE5, an enzyme that breaks down cyclic guanosine monophosphate (cGMP). cGMP relaxes smooth muscles and widens blood vessels in the penis, increasing blood flow and causing an erection during sexual stimulation. Sildenafil enhances Nitric Oxide (NO) effect by preventing cGMP degradation. Sexual stimulation is required for Sildenafil to work for erectile dysfunction.
• Pulmonary Arterial Hypertension: Sildenafil inhibits PDE-5 in the smooth muscles of the pulmonary vasculature, which prevents cGMP degradation and helps to relax the arteries. When the arteries in the lungs relax and widen, it's easier for the heart to pump blood through, which reduces blood pressure in the lungs and improves the ability to exercise.

Benefits:

• Treatment of ED: Sildenafil is effective as an oral treatment for ED because it facilitates penile erection by relaxing the corpus cavernosum.
• Management of PAH: Sildenafil helps manage PAH by widening the arteries in the lungs, making it easier for the heart to pump blood and thereby reducing blood pressure.
• Improved exercise capacity: Sildenafil enhances a person's ability to exercise by reducing pulmonary blood pressure.
• Sustained Vasodilation: Sildenafil helps sustain vasodilation by increasing endothelial generation of NO via activated eNOS.
• The effects of Sildenafil can last up to 18 hours, with an onset of action within 30 minutes.

Dosage and how to take Assurans Injection

Assurans Injection is prescription-based and should be taken as per a healthcare professional's instructions.

However, you can follow a few steps to increase the effectiveness of this medication:

• A certified doctor should administer the Injection in a hospital or clinical facility. For PAH, it is usually taken three times a day. For ED, it should be used as needed one hour before sexual activity. Follow the prescribed dosage by your doctor.
• It is injected directly into the penile tissue (intracavernosal) for ED or a vein (intravenous) for specific medical conditions in newborns.
• Take 30 to 60 minutes before intercourse and at least 2 hours after a meal. Change Injection sites to prevent tissue damage.
• If you miss your dose of Assurans, take the medication as soon as you remember, but skip the missing dose if your next dose is coming up. Do not stop taking it without consulting your doctor, as it may worsen your symptoms.

Side effects

Like any medication, Assurans may cause some side effects. These adverse effects are temporary and will subside as your body adjusts.

However, consult a healthcare professional if the side effects persist or worsen.

The side effects of using Assurans are as follows:

• Flushing
• Headache
• Indigestion
• Muscle Pain
• Upset Stomach
• Rash

Interactions

Like most medications, Assurans​​ may interact with other medicines you take, your health conditions, or specific foods or drinks.

Drug interactions

Assurans can interact with other medications, which could alter their effectiveness or increase the risk of adverse effects.

• Nitrates: Should not be taken with nitrates, often given for chest pain, as it can cause a severe and potentially fatal fall in blood pressure.
• Alpha-blockers: Interact with alpha-blockers, which are used for high blood pressure or prostate problems.
• Other PDE5 inhibitors: Use with other PDE5 inhibitors can lead to additive effects.
• Blood pressure-lowering medicines: When used with blood pressure-lowering medication, it can cause a severe fall in blood pressure.

To avoid harmful interactions, always provide your healthcare provider with a complete list of all medications, including over-the-counter drugs and supplements.

Disease interactions

When taking Assurans, being aware of potential disease interactions is essential. You should not take Injection unless your doctor advises you to do so if you are suffering from the following diseases:

• Heart disease: Assurans may have mild side effects on the heart.
• Pulmonary Arterial Hypertension
• Kidney disease: Inform your health care provider if you have any underlying kidney disease. A lower dose may be considered if the medication is not well tolerated. There may be some adverse effects on the kidney after taking Assurans.
• Liver disease: Assurans are not recommended in patients with severe liver diseases.
• History of stroke or heart attack: Do not take this medicine if you have recently had a stroke or heart attack.
• Retinitis pigmentosa
• Stomach ulcers

Food interactions

The following are essential points regarding food interactions with this Injection (Sildenafil):

• Grapefruit/grapefruit juice: Avoid consuming grapefruit or grapefruit juice while using Assurans, as it may increase the risk of side effects.
• High-fat meals: Taking Sildenafil with a high-fat meal might delay the onset of action.
• Citrus fruits: After taking the medicine, it is essential to avoid citrus fruits, especially grapefruit, because they affect the drug's absorption.

• Caution with alcohol: Consult your doctor before consuming alcohol while taking this Injection, as it can have severe side effects.

These recommendations aim to optimize the effectiveness of the medication and minimize any potential severity of respiratory symptoms.

Precautions

Here are a few of the precautions to be taken before using this Injection:

• Pregnant or breastfeeding women: Always consult a doctor before using Seroflo during pregnancy or while breastfeeding to assess the benefits and risks involved.

• Allergies: Do not use Assurans if you are allergic to any components.
• Driving and concentration: Assurans may cause dizziness or sleepiness, so avoid driving or activities requiring concentration until you know how it affects you.
• Do not stop suddenly: Do not stop taking the medication immediately without consulting to your healthcare provider, as this may worsen your symptoms.

Following these precautions assures the patients of the benefits and minimal negative impacts of the Injection under medical supervision.

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FAQs

Can I get Assurans Injection without a prescription?

No, you cannot obtain Injection without a prescription. It is classified as a prescription medication, requiring a doctor's approval for safe administration and monitoring due to potential side effects and reactions.

Can I take Assurans Injections for the rest of my life?

Yes, it is generally considered safe for long-term use in treating Pulmonary Arterial Hypertension. However, it should only be taken under medical supervision, as discontinuation without consulting a doctor may worsen symptoms or lead to complications.

Why is the use of Assurans Injection contraindicated with nitrates?

Assurans is contraindicated with nitrates because both medications can significantly lower Blood Pressure. This combination may lead to dangerous hypotension, increasing the risk of severe cardiovascular complications, particularly in patients with heart conditions.

Why does an Assurans Injection cause a fall in Blood Pressure (hypotension)?

Assurans causes hypotension by relaxing and widening blood vessels, which lowers Blood Pressure. This effect can be dangerous, especially when combined with other blood pressure-lowering medications or nitrates, potentially leading to severe drops in blood pressure.

How long does it take for an Assurans Injection to start working?

Assurans may start to work immediately after administration. For ED, it is very effective and must be taken at least half an hour before engaging in sexual activity. Injectable Alprostadil should produce an erection within 5 to 20 minutes.